Supramolecular inhibition of amyloid fibrillation by cucurbit[7]uril

Hong Hee Lee, Tae Su Choi, Shin Jung C. Lee, Jong Wha Lee, Junghong Park, Young Ho Ko, Won Jong Kim, Kimoon Kim, Hugh I. Kim

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Amyloid fibrils are insoluble protein aggregates comprised of highly ordered β-sheet structures and they are involved in the pathology of amyloidoses, such as Alzheimer's disease. A supramolecular strategy is presented for inhibiting amyloid fibrillation by using cucurbit[7]uril (CB[7]). CB[7] prevents the fibrillation of insulin and β-amyloid by capturing phenylalanine (Phe) residues, which are crucial to the hydrophobic interactions formed during amyloid fibrillation. These results suggest that the Phe-specific binding of CB[7] can modulate the intermolecular interaction of amyloid proteins and prevent the transition from monomeric to multimeric states. CB[7] thus has potential for the development of a therapeutic strategy for amyloidosis.

Original languageEnglish
Pages (from-to)7461-7465
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number29
DOIs
Publication statusPublished - 2014 Jul 14
Externally publishedYes

Fingerprint

Amyloid
Phenylalanine
Amyloidogenic Proteins
Insulin
Pathology
Proteins
cucurbit(7)uril

Keywords

  • aggregation
  • cucurbit[7]uril
  • insulin
  • supramolecular chemistry
  • β-amyloid

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Supramolecular inhibition of amyloid fibrillation by cucurbit[7]uril. / Lee, Hong Hee; Choi, Tae Su; Lee, Shin Jung C.; Lee, Jong Wha; Park, Junghong; Ko, Young Ho; Kim, Won Jong; Kim, Kimoon; Kim, Hugh I.

In: Angewandte Chemie - International Edition, Vol. 53, No. 29, 14.07.2014, p. 7461-7465.

Research output: Contribution to journalArticle

Lee, HH, Choi, TS, Lee, SJC, Lee, JW, Park, J, Ko, YH, Kim, WJ, Kim, K & Kim, HI 2014, 'Supramolecular inhibition of amyloid fibrillation by cucurbit[7]uril', Angewandte Chemie - International Edition, vol. 53, no. 29, pp. 7461-7465. https://doi.org/10.1002/anie.201402496
Lee, Hong Hee ; Choi, Tae Su ; Lee, Shin Jung C. ; Lee, Jong Wha ; Park, Junghong ; Ko, Young Ho ; Kim, Won Jong ; Kim, Kimoon ; Kim, Hugh I. / Supramolecular inhibition of amyloid fibrillation by cucurbit[7]uril. In: Angewandte Chemie - International Edition. 2014 ; Vol. 53, No. 29. pp. 7461-7465.
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