Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery

Chao Feng, Jing Li, Ming Kong, Ya Liu, Xiao Jie Cheng, Yang Li, Hyun Jin Park, Xi Guang Chen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To develop more effective anticancer mucoadhesive drug delivery system for the treatment of colorectal cancer, chitosan based nanogels (NGs) were prepared by electrostatic interaction between chitosan (CS) and carboxymethyl-chitosan (CMCS). By respectively using tripolyphosphate (TPP) and CaCl<inf>2</inf> as ionic crosslinker, two well-characterized doxorubicin hydrochloride (DOX) loaded NGs with opposite zeta potential (DOX:CS/CMCS/TPP NGs, -32.6±1.1mV and DOX:CS/CMCS/Ca<sup>2+</sup> NGs, +31.8±0.9mV) were obtained. Compared with DOX:CS/CMCS/TPP NGs, DOX:CS/CMCS/Ca<sup>2+</sup> NGs were taken up to a greater extent by colorectal cancer cells, resulting in greater reduction in percentage of cell viability. Owing to high binding capability to mucin and inhibited paracellular transport by colon, DOX:CS/CMCS/Ca<sup>2+</sup> NGs exhibited improved mucoadhesion and limited permeability. This is beneficial to prolong the contact time of formulation onto intestinal mucosa and improved local drug concentration. The results provided evidence DOX:CS/CMCS/Ca<sup>2+</sup> NGs to be exciting and promising for the treatment of colorectal cancer.

Original languageEnglish
Pages (from-to)439-447
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume128
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • Cellular uptake
  • Chitosan
  • Colorectal cancer
  • Mucoadhesion
  • Nanogels

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

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