Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

Sangyeop Lee, Hyangah Chon, Moonkwon Lee, Jaebum Choo, Soon Young Shin, Young Han Lee, Im Joo Rhyu, Sang Wook Son, Chil Hwan Oh

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.

Original languageEnglish
Pages (from-to)2260-2263
Number of pages4
JournalBiosensors and Bioelectronics
Volume24
Issue number7
DOIs
Publication statusPublished - 2009 Mar 15

Fingerprint

Nanospheres
Raman Spectrum Analysis
MCF-7 Cells
Antibodies
Gold
Raman scattering
Imaging techniques
Neoplasms
Silver
Nanoparticles
Scattering

Keywords

  • Cancer marker
  • Cellular imaging
  • Hollow gold nanosphere
  • Homogeneous sensing probe
  • Surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

Cite this

Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres. / Lee, Sangyeop; Chon, Hyangah; Lee, Moonkwon; Choo, Jaebum; Shin, Soon Young; Lee, Young Han; Rhyu, Im Joo; Son, Sang Wook; Oh, Chil Hwan.

In: Biosensors and Bioelectronics, Vol. 24, No. 7, 15.03.2009, p. 2260-2263.

Research output: Contribution to journalArticle

Lee, Sangyeop ; Chon, Hyangah ; Lee, Moonkwon ; Choo, Jaebum ; Shin, Soon Young ; Lee, Young Han ; Rhyu, Im Joo ; Son, Sang Wook ; Oh, Chil Hwan. / Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres. In: Biosensors and Bioelectronics. 2009 ; Vol. 24, No. 7. pp. 2260-2263.
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