Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

Sangyeop Lee; Hyangah Chon; Moonkwon Lee; Jaebum Choo; Soon Young Shin; Young Han Lee; Im Joo Rhyu; Sang Wook Son; Chil Hwan Oh

doi:10.1016/j.bios.2008.10.018

Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

Sangyeop Lee, Hyangah Chon, Moonkwon Lee, Jaebum Choo, Soon Young Shin, Young Han Lee, Im Joo Rhyu, Sang Wook Son, Chil Hwan Oh

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

167 Citations (Scopus)

Abstract

Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.

Original language	English
Pages (from-to)	2260-2263
Number of pages	4
Journal	Biosensors and Bioelectronics
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/j.bios.2008.10.018
Publication status	Published - 2009 Mar 15

Keywords

Cancer marker
Cellular imaging
Hollow gold nanosphere
Homogeneous sensing probe
Surface-enhanced Raman scattering

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bios.2008.10.018

Cite this

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title = "Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres",

abstract = "Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.",

keywords = "Cancer marker, Cellular imaging, Hollow gold nanosphere, Homogeneous sensing probe, Surface-enhanced Raman scattering",

author = "Sangyeop Lee and Hyangah Chon and Moonkwon Lee and Jaebum Choo and Shin, {Soon Young} and Lee, {Young Han} and Rhyu, {Im Joo} and Son, {Sang Wook} and Oh, {Chil Hwan}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (grant numbers R01-2007-000-20238-0 and R11-2008-044-01002-0), the National Cancer Center of Korea (grant number 0620400-1) and the Seoul Research and Business Development Program (grant number 10574).",

year = "2009",

month = mar,

day = "15",

doi = "10.1016/j.bios.2008.10.018",

language = "English",

volume = "24",

pages = "2260--2263",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

AU - Lee, Sangyeop

AU - Chon, Hyangah

AU - Lee, Moonkwon

AU - Choo, Jaebum

AU - Shin, Soon Young

AU - Lee, Young Han

AU - Rhyu, Im Joo

AU - Son, Sang Wook

AU - Oh, Chil Hwan

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (grant numbers R01-2007-000-20238-0 and R11-2008-044-01002-0), the National Cancer Center of Korea (grant number 0620400-1) and the Seoul Research and Business Development Program (grant number 10574).

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.

AB - Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.

KW - Cancer marker

KW - Cellular imaging

KW - Hollow gold nanosphere

KW - Homogeneous sensing probe

KW - Surface-enhanced Raman scattering

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U2 - 10.1016/j.bios.2008.10.018

DO - 10.1016/j.bios.2008.10.018

M3 - Article

C2 - 19056254

AN - SCOPUS:60349119849

VL - 24

SP - 2260

EP - 2263

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

SN - 0956-5663

IS - 7

ER -

Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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