Surface immobilization of biphasic calcium phosphate nanoparticles on 3D printed poly(caprolactone) scaffolds enhances osteogenesis and bone tissue regeneration

Kyu Sik Shim, Sung Eun Kim, Young Pil Yun, Daniel I. Jeon, Hak Jun Kim, Kyeongsoon Park, Hae Ryong Song

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We fabricated biphasic calcium phosphate nanoparticles (BCP NPs)-immobilized on the surface of 3D printed PCL (BCP-IM-PCL) scaffolds, and evaluated in vitro osteogenesis and in vivo new bone formation in rat tibial defect model. In vitro and in vivo studies showed that BCP-IM-PCL significantly enhanced osteogenic markers (i.e., ALP activity, calcium deposition, and the expression of osteocalcin and osteopontin) and markedly increased new bone formation and mineralized bone tissues in tibial defect area, compared to unmodified PCL and BCP-mixed PCL scaffolds. This study demonstrated that BCP NPs-immobilized on the surface of PCL scaffolds are promising templates for bone tissue regeneration.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
Volume55
DOIs
Publication statusPublished - 2017 Nov 25

Keywords

  • Biphasic calcium phosphate (BCP)
  • MG-63 cells
  • New bone formation
  • Three-dimensional (3D) printed scaffolds
  • Tibial defect model

ASJC Scopus subject areas

  • Chemical Engineering(all)

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