Surface properties of liposomes modified with poly(ethylenimine)

Jung Park Yun, Eun Nam Da, Hoan Seo Dong, Dong Han Hee, Tae Woo Kim, Suk Kim Moon, Byung Cheol Shin

Research output: Contribution to journalArticle

Abstract

Cationic liposomes for cancer treatment have been developed in the field of chemotharpy. It was well combined on the surface of anionic tumor cell membrane by electrostatic interaction. Thus, the object of this study was to prepare the cationic liposomes capable of forming an ionic complex with the anionic cell membrane. To prepare the cationic liposomes, 1,2-distearoyl-sn-glycero-3- phosphoethanolamine (DSPE) as a cationic lipid material and polyethylenimine (PEI) as a cationic polymer were synthesized. Ionic property on the surface of liposomes was determined by the zeta potential. The adsorption characteristics of plasma protein for liposome in bovine serum were determined by the particle size and turbidity change. To estimate the stability of liposome in buffered solution, the change of particle size was measured at room temperature for seven days. The cationic liposomes were absorbed a large amount of plasma protein in bovine serum because plasma protein having anionic charge was fixed on the surface of cationic liposomes. This result indicate that the modification on the surface of liposomes using cationic polyethylenimine enhances the protein adsorption in bovine serum. Additionaly, cationic liposomes showed good stability in buffered solution for seven days.

Original languageEnglish
Pages (from-to)502-508
Number of pages7
JournalPolymer (Korea)
Volume28
Issue number6
Publication statusPublished - 2004 Nov 1
Externally publishedYes

Fingerprint

Liposomes
Surface properties
Proteins
Polyethyleneimine
Blood Proteins
Cell membranes
Plasmas
Particle size
aziridine
Adsorption
Oncology
Turbidity
Zeta potential
Coulomb interactions
Lipids
Tumors
Polymers

Keywords

  • Cationic liposomes
  • Poly(ethylenimine)
  • Protein adsorption
  • Stability

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Yun, J. P., Da, E. N., Dong, H. S., Hee, D. H., Kim, T. W., Moon, S. K., & Shin, B. C. (2004). Surface properties of liposomes modified with poly(ethylenimine). Polymer (Korea), 28(6), 502-508.

Surface properties of liposomes modified with poly(ethylenimine). / Yun, Jung Park; Da, Eun Nam; Dong, Hoan Seo; Hee, Dong Han; Kim, Tae Woo; Moon, Suk Kim; Shin, Byung Cheol.

In: Polymer (Korea), Vol. 28, No. 6, 01.11.2004, p. 502-508.

Research output: Contribution to journalArticle

Yun, JP, Da, EN, Dong, HS, Hee, DH, Kim, TW, Moon, SK & Shin, BC 2004, 'Surface properties of liposomes modified with poly(ethylenimine)', Polymer (Korea), vol. 28, no. 6, pp. 502-508.
Yun JP, Da EN, Dong HS, Hee DH, Kim TW, Moon SK et al. Surface properties of liposomes modified with poly(ethylenimine). Polymer (Korea). 2004 Nov 1;28(6):502-508.
Yun, Jung Park ; Da, Eun Nam ; Dong, Hoan Seo ; Hee, Dong Han ; Kim, Tae Woo ; Moon, Suk Kim ; Shin, Byung Cheol. / Surface properties of liposomes modified with poly(ethylenimine). In: Polymer (Korea). 2004 ; Vol. 28, No. 6. pp. 502-508.
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