Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling-deswelling methods with phospholipids moiety containing ABA-type block copolymers

Ji-Hun Seo, Ryosuke Matsuno, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

The surface modification of poly(dimethylsiloxane) (PDMS) substrates by using ABA-type block copolymers comprising poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) and PDMS segments was investigated. The hydrophobic interaction between the swelling-deswelling nature of PDMS and PDMS segments in block copolymers was the main mechanism for surface modification. Block copolymers with various compositions were synthesized by using the atom transfer radical polymerization (ATRP) method. The kinetic plots revealed that polymerization could be initiated by PDMS macroinitiators and it proceeds in a well-controlled manner; therefore, the compositions of the block copolymers were controllable. The obtained block copolymers were dissolved in a chloroform/ethanol mixed solvent. The surface of the PDMS substrate was modified using block copolymers by the swelling-deswelling method. Static contact angle and X-ray photoelectron spectroscopy (XPS) measurements revealed that the hydrophobic surface of the PDMS substrate was converted to a hydrophilic surface because of modification by surface-tethered PMPC segments. Protein adsorption test and L929 cell adhesion test were carried out for evaluating the biocompatibility. As observed, the amount of adsorbed proteins and cell adhesion were drastically reduced as compared to those in the non-treated PDMS substrate. We conclude that this procedure is effective in fabricating biocompatible surfaces on PDMS substrates.

Original languageEnglish
Pages (from-to)1367-1376
Number of pages10
JournalBiomaterials
Volume29
Issue number10
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Fingerprint

Phosphorylcholine
Phospholipids
Polydimethylsiloxane
Block copolymers
Swelling
Substrates
Cell adhesion
Cell Adhesion
Polymerization
Surface treatment
Proteins
baysilon
Photoelectron Spectroscopy
Atom transfer radical polymerization
Chloroform
Chlorine compounds
Chemical analysis
Hydrophobic and Hydrophilic Interactions
Biocompatibility
Adsorption

Keywords

  • 2-Methacryloyloxyethyl phosphorylcholine
  • Atom transfer radical polymerization
  • Biocompatibility
  • Poly(dimethylsiloxane)
  • Swelling-deswelling method

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling-deswelling methods with phospholipids moiety containing ABA-type block copolymers. / Seo, Ji-Hun; Matsuno, Ryosuke; Konno, Tomohiro; Takai, Madoka; Ishihara, Kazuhiko.

In: Biomaterials, Vol. 29, No. 10, 01.04.2008, p. 1367-1376.

Research output: Contribution to journalArticle

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