Surface vulnerability of cerebral cortex to major depressive disorder

Daihui Peng, Feng Shi, Gang Li, Drew Fralick, Ting Shen, Meihui Qiu, Jun Liu, Kaida Jiang, Dinggang Shen, Yiru Fang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Major depressive disorder (MDD) is accompanied by atypical brain structure. This study first presents the alterations in the cortical surface of patients with MDD using multidimensional structural patterns that reflect different neurodevelopment. Sixteen first-episode, untreated patients with MDD and 16 matched healthy controls underwent a magnetic resonance imaging (MRI) scan. The cortical maps of thickness, surface area, and gyrification were examined using the surface-based morphometry (SBM) approach. Increase of cortical thickness was observed in the right posterior cingulate region and the parietal cortex involving the bilateral inferior, left superior parietal and right paracentral regions, while decreased thickness was noted in the parietal cortex including bilateral pars opercularis and left precentral region, as well as the left rostral-middle frontal regions in patients with MDD. Likewise, increased or decreased surface area was found in five sub-regions of the cingulate gyrus, parietal and frontal cortices (e.g., bilateral inferior parietal and superior frontal regions). In addition, MDD patients exhibited a significant hypergyrification in the right precentral and supramarginal region. This integrated structural assessment of cortical surface suggests that MDD patients have cortical alterations of the frontal, parietal and cingulate regions, indicating a vulnerability to MDD during earlier neurodevelopmental process.

Original languageEnglish
Article numbere0120704
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - 2015 Mar 20
Externally publishedYes

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cerebral cortex
Major Depressive Disorder
Cerebral Cortex
Parietal Lobe
Gyrus Cinguli
surface area
cortex
neurodevelopment
Magnetic resonance
morphometry
magnetic resonance imaging
Brain
Frontal Lobe
brain
Imaging techniques
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Peng, D., Shi, F., Li, G., Fralick, D., Shen, T., Qiu, M., ... Fang, Y. (2015). Surface vulnerability of cerebral cortex to major depressive disorder. PLoS One, 10(3), [e0120704]. https://doi.org/10.1371/journal.pone.0120704

Surface vulnerability of cerebral cortex to major depressive disorder. / Peng, Daihui; Shi, Feng; Li, Gang; Fralick, Drew; Shen, Ting; Qiu, Meihui; Liu, Jun; Jiang, Kaida; Shen, Dinggang; Fang, Yiru.

In: PLoS One, Vol. 10, No. 3, e0120704, 20.03.2015.

Research output: Contribution to journalArticle

Peng, D, Shi, F, Li, G, Fralick, D, Shen, T, Qiu, M, Liu, J, Jiang, K, Shen, D & Fang, Y 2015, 'Surface vulnerability of cerebral cortex to major depressive disorder', PLoS One, vol. 10, no. 3, e0120704. https://doi.org/10.1371/journal.pone.0120704
Peng D, Shi F, Li G, Fralick D, Shen T, Qiu M et al. Surface vulnerability of cerebral cortex to major depressive disorder. PLoS One. 2015 Mar 20;10(3). e0120704. https://doi.org/10.1371/journal.pone.0120704
Peng, Daihui ; Shi, Feng ; Li, Gang ; Fralick, Drew ; Shen, Ting ; Qiu, Meihui ; Liu, Jun ; Jiang, Kaida ; Shen, Dinggang ; Fang, Yiru. / Surface vulnerability of cerebral cortex to major depressive disorder. In: PLoS One. 2015 ; Vol. 10, No. 3.
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