Surgical outcomes and prognostic factors for T2 gallbladder cancer following surgical resection

Sae-Byeol Choi, Hyung Joon Han, Chung Yun Kim, Wan-Bae Kim, Taejin Song, Sung Ock Suh, Young Chul Kim, Sang Yong Choi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Depth of tumor invasion is an important prognostic factor for gallbladder cancer. The aim of this study was to investigate the clinicopathological prognostic factors of T2 gallbladder cancer. Methods: We retrospectively reviewed the clinicopathological data and survival for 83 patients with T2 gallbladder cancers who underwent surgical resection between January 1995 and December 2007. Results: The overall survival rates were 48. 9% at 3 years and 29. 3% at 5 years. Univariate analysis revealed that R0 resection (P < 0. 001), extended surgery (P = 0. 028), lymph node dissection (P = 0. 024), non-infiltrative tumors (P = 0. 001), well differentiation (P = 0. 001), absence of lymphatic (P = 0. 025), perineural (P = 0. 001), and vascular (P = 0. 025) invasion, absence of lymph node metastasis (P = 0. 001), negative resection margin (P = 0. 016), and stage (P = 0. 002) were significantly better predictors for survival. A significant difference in survival between Rx and R1 was not found. R0 resection, lymph node dissection, well differentiation, and absence of perineural and vascular invasion were significantly independent prognostic factors for overall survival. Recurrence occurred in 48 patients (57. 8%). Age older than 65 years, R0 resection, non-infiltrative tumors, and good differentiation were significant independent predictors of disease-free survival by multivariate analysis. Conclusions: For T2 tumors, radical surgery including lymph node dissection should be performed to achieve R0 resection. Tumors with infiltrative types and suspicious lymph node metastasis in the intraoperative findings were candidates for aggressive surgical management to improve patient survival.

Original languageEnglish
Pages (from-to)668-678
Number of pages11
JournalJournal of Gastrointestinal Surgery
Volume14
Issue number4
DOIs
Publication statusPublished - 2010 Apr 1

Fingerprint

Gallbladder Neoplasms
Lymph Node Excision
Survival
Neoplasms
Blood Vessels
Lymph Nodes
Neoplasm Metastasis
Survival Analysis
Disease-Free Survival
Multivariate Analysis
Survival Rate
Recurrence

Keywords

  • Cholecystectomy
  • Lymph node dissection
  • Radical surgery
  • T2 gallbladder cancer

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Surgical outcomes and prognostic factors for T2 gallbladder cancer following surgical resection. / Choi, Sae-Byeol; Han, Hyung Joon; Kim, Chung Yun; Kim, Wan-Bae; Song, Taejin; Suh, Sung Ock; Kim, Young Chul; Choi, Sang Yong.

In: Journal of Gastrointestinal Surgery, Vol. 14, No. 4, 01.04.2010, p. 668-678.

Research output: Contribution to journalArticle

@article{1bf616724c114513b765fc194ce31dc7,
title = "Surgical outcomes and prognostic factors for T2 gallbladder cancer following surgical resection",
abstract = "Background: Depth of tumor invasion is an important prognostic factor for gallbladder cancer. The aim of this study was to investigate the clinicopathological prognostic factors of T2 gallbladder cancer. Methods: We retrospectively reviewed the clinicopathological data and survival for 83 patients with T2 gallbladder cancers who underwent surgical resection between January 1995 and December 2007. Results: The overall survival rates were 48. 9{\%} at 3 years and 29. 3{\%} at 5 years. Univariate analysis revealed that R0 resection (P < 0. 001), extended surgery (P = 0. 028), lymph node dissection (P = 0. 024), non-infiltrative tumors (P = 0. 001), well differentiation (P = 0. 001), absence of lymphatic (P = 0. 025), perineural (P = 0. 001), and vascular (P = 0. 025) invasion, absence of lymph node metastasis (P = 0. 001), negative resection margin (P = 0. 016), and stage (P = 0. 002) were significantly better predictors for survival. A significant difference in survival between Rx and R1 was not found. R0 resection, lymph node dissection, well differentiation, and absence of perineural and vascular invasion were significantly independent prognostic factors for overall survival. Recurrence occurred in 48 patients (57. 8{\%}). Age older than 65 years, R0 resection, non-infiltrative tumors, and good differentiation were significant independent predictors of disease-free survival by multivariate analysis. Conclusions: For T2 tumors, radical surgery including lymph node dissection should be performed to achieve R0 resection. Tumors with infiltrative types and suspicious lymph node metastasis in the intraoperative findings were candidates for aggressive surgical management to improve patient survival.",
keywords = "Cholecystectomy, Lymph node dissection, Radical surgery, T2 gallbladder cancer",
author = "Sae-Byeol Choi and Han, {Hyung Joon} and Kim, {Chung Yun} and Wan-Bae Kim and Taejin Song and Suh, {Sung Ock} and Kim, {Young Chul} and Choi, {Sang Yong}",
year = "2010",
month = "4",
day = "1",
doi = "10.1007/s11605-009-1132-z",
language = "English",
volume = "14",
pages = "668--678",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Surgical outcomes and prognostic factors for T2 gallbladder cancer following surgical resection

AU - Choi, Sae-Byeol

AU - Han, Hyung Joon

AU - Kim, Chung Yun

AU - Kim, Wan-Bae

AU - Song, Taejin

AU - Suh, Sung Ock

AU - Kim, Young Chul

AU - Choi, Sang Yong

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Background: Depth of tumor invasion is an important prognostic factor for gallbladder cancer. The aim of this study was to investigate the clinicopathological prognostic factors of T2 gallbladder cancer. Methods: We retrospectively reviewed the clinicopathological data and survival for 83 patients with T2 gallbladder cancers who underwent surgical resection between January 1995 and December 2007. Results: The overall survival rates were 48. 9% at 3 years and 29. 3% at 5 years. Univariate analysis revealed that R0 resection (P < 0. 001), extended surgery (P = 0. 028), lymph node dissection (P = 0. 024), non-infiltrative tumors (P = 0. 001), well differentiation (P = 0. 001), absence of lymphatic (P = 0. 025), perineural (P = 0. 001), and vascular (P = 0. 025) invasion, absence of lymph node metastasis (P = 0. 001), negative resection margin (P = 0. 016), and stage (P = 0. 002) were significantly better predictors for survival. A significant difference in survival between Rx and R1 was not found. R0 resection, lymph node dissection, well differentiation, and absence of perineural and vascular invasion were significantly independent prognostic factors for overall survival. Recurrence occurred in 48 patients (57. 8%). Age older than 65 years, R0 resection, non-infiltrative tumors, and good differentiation were significant independent predictors of disease-free survival by multivariate analysis. Conclusions: For T2 tumors, radical surgery including lymph node dissection should be performed to achieve R0 resection. Tumors with infiltrative types and suspicious lymph node metastasis in the intraoperative findings were candidates for aggressive surgical management to improve patient survival.

AB - Background: Depth of tumor invasion is an important prognostic factor for gallbladder cancer. The aim of this study was to investigate the clinicopathological prognostic factors of T2 gallbladder cancer. Methods: We retrospectively reviewed the clinicopathological data and survival for 83 patients with T2 gallbladder cancers who underwent surgical resection between January 1995 and December 2007. Results: The overall survival rates were 48. 9% at 3 years and 29. 3% at 5 years. Univariate analysis revealed that R0 resection (P < 0. 001), extended surgery (P = 0. 028), lymph node dissection (P = 0. 024), non-infiltrative tumors (P = 0. 001), well differentiation (P = 0. 001), absence of lymphatic (P = 0. 025), perineural (P = 0. 001), and vascular (P = 0. 025) invasion, absence of lymph node metastasis (P = 0. 001), negative resection margin (P = 0. 016), and stage (P = 0. 002) were significantly better predictors for survival. A significant difference in survival between Rx and R1 was not found. R0 resection, lymph node dissection, well differentiation, and absence of perineural and vascular invasion were significantly independent prognostic factors for overall survival. Recurrence occurred in 48 patients (57. 8%). Age older than 65 years, R0 resection, non-infiltrative tumors, and good differentiation were significant independent predictors of disease-free survival by multivariate analysis. Conclusions: For T2 tumors, radical surgery including lymph node dissection should be performed to achieve R0 resection. Tumors with infiltrative types and suspicious lymph node metastasis in the intraoperative findings were candidates for aggressive surgical management to improve patient survival.

KW - Cholecystectomy

KW - Lymph node dissection

KW - Radical surgery

KW - T2 gallbladder cancer

UR - http://www.scopus.com/inward/record.url?scp=77950520839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950520839&partnerID=8YFLogxK

U2 - 10.1007/s11605-009-1132-z

DO - 10.1007/s11605-009-1132-z

M3 - Article

C2 - 20033339

AN - SCOPUS:77950520839

VL - 14

SP - 668

EP - 678

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 4

ER -