Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea

Mi Ran Seo, Seong Jong Kim, Yeonjae Kim, Jieun Kim, Tae Yeal Choi, Jung Oak Kang, Seong Heon Wie, Moran Ki, Young Kyun Cho, Seung Kwan Lim, Jin Seo Lee, Ki Tae Kwon, Hyuck Lee, Hee-Jin Cheong, Dae Won Park, Seong Yeol Ryu, Moon Hyun Chung, Hyunjoo Pai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.

Original languageEnglish
Pages (from-to)1178-1181
Number of pages4
JournalJournal of Korean Medical Science
Volume29
Issue number8
DOIs
Publication statusPublished - 2014 Jan 1

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Fosfomycin
Community-Acquired Infections
Nitrofurantoin
Korea
Urinary Tract Infections
Escherichia coli
Polytetrafluoroethylene
Ciprofloxacin
Sulfamethoxazole
Sulfamethoxazole Drug Combination Trimethoprim
Agar
Guidelines
Anti-Bacterial Agents
temocillin
Therapeutics
Pharmaceutical Preparations

Keywords

  • Cefepime
  • Ciprofloxacin
  • Community-acquired infections
  • Escherichia coli
  • Fosfomycin
  • Minimal inhibitory concentration
  • Nitrofurantoin
  • Temocillin
  • Trimethoprim-sulfamethoxazole combination
  • Urinary tract

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea. / Seo, Mi Ran; Kim, Seong Jong; Kim, Yeonjae; Kim, Jieun; Choi, Tae Yeal; Kang, Jung Oak; Wie, Seong Heon; Ki, Moran; Cho, Young Kyun; Lim, Seung Kwan; Lee, Jin Seo; Kwon, Ki Tae; Lee, Hyuck; Cheong, Hee-Jin; Park, Dae Won; Ryu, Seong Yeol; Chung, Moon Hyun; Pai, Hyunjoo.

In: Journal of Korean Medical Science, Vol. 29, No. 8, 01.01.2014, p. 1178-1181.

Research output: Contribution to journalArticle

Seo, MR, Kim, SJ, Kim, Y, Kim, J, Choi, TY, Kang, JO, Wie, SH, Ki, M, Cho, YK, Lim, SK, Lee, JS, Kwon, KT, Lee, H, Cheong, H-J, Park, DW, Ryu, SY, Chung, MH & Pai, H 2014, 'Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea', Journal of Korean Medical Science, vol. 29, no. 8, pp. 1178-1181. https://doi.org/10.3346/jkms.2014.29.8.1178
Seo, Mi Ran ; Kim, Seong Jong ; Kim, Yeonjae ; Kim, Jieun ; Choi, Tae Yeal ; Kang, Jung Oak ; Wie, Seong Heon ; Ki, Moran ; Cho, Young Kyun ; Lim, Seung Kwan ; Lee, Jin Seo ; Kwon, Ki Tae ; Lee, Hyuck ; Cheong, Hee-Jin ; Park, Dae Won ; Ryu, Seong Yeol ; Chung, Moon Hyun ; Pai, Hyunjoo. / Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea. In: Journal of Korean Medical Science. 2014 ; Vol. 29, No. 8. pp. 1178-1181.
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abstract = "With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100{\%} (346/346), TMO 96.8{\%} (335/346), and NI 99.4{\%} (344/346). Conversely, resistance rates of CIP and SMX were 22{\%} (76/346) and 29.2{\%} (101/349), respectively. FEP still retained an activity of 98.5{\%}. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.",
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AU - Kim, Seong Jong

AU - Kim, Yeonjae

AU - Kim, Jieun

AU - Choi, Tae Yeal

AU - Kang, Jung Oak

AU - Wie, Seong Heon

AU - Ki, Moran

AU - Cho, Young Kyun

AU - Lim, Seung Kwan

AU - Lee, Jin Seo

AU - Kwon, Ki Tae

AU - Lee, Hyuck

AU - Cheong, Hee-Jin

AU - Park, Dae Won

AU - Ryu, Seong Yeol

AU - Chung, Moon Hyun

AU - Pai, Hyunjoo

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N2 - With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.

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