Sympathetic sprouting in sensory ganglia depends on the number of injured neurons

Jin Kim Hee Jin Kim, Sik Na Heung Sik Na, Keun Back Seung Keun Back, Kil Hong Seung Kil Hong

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We examined whether the extent of sympathetic sprouting in the dorsal root ganglion was a function of the number of injured nerve fibers. We compared two groups of rats. One group was subjected to unilateral superior and inferior caudal trunk transections at the level between the S1 and S2 spinal nerves (S-I group) and the other group was subjected to unilateral superior caudal trunk transection at the same level (S group). Immunohistochemical staining with tyrosine hydroxylase (TH) antibody of the S1 DRG revealed that the degree of TH-immunoreactive fibers was more extensive in the S-I group than in the S group. However, there was no difference in the severity of neuropathic pain behaviors between the two groups. These results suggest that the extent of sympathetic sprouting in the DRG following peripheral nerve injury is proportionally related to the amount of injured nerve fibers, but not related to the degree of neuropathic pain behaviors.

Original languageEnglish
Pages (from-to)3529-3532
Number of pages4
JournalNeuroreport
Volume12
Issue number16
Publication statusPublished - 2001 Nov 16

Keywords

  • Allodynia
  • Dorsal root ganglion
  • Neuropathic pain
  • Peripheral neuropathy
  • Sympathetic sprouting

ASJC Scopus subject areas

  • Neuroscience(all)

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