Synapses need coordination to learn motor skills

Kea Joo Lee, Im Joo Rhyu, Daniel T.S. Pak

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Experience-dependent remodeling of synaptic structure and function underlies information storage in the mammalian central nervous system. Although accumulating evidence suggests synergistic roles of long-term depression (LTD) and long-term potentiation (LTP) in cerebellar motor learning, their structural correlates and operational mechanisms have not been clearly addressed. A recent three-dimensional electron microscopic study provides insight for a potential complementary interplay between LTP and LTD in local dendritic segments of Purkinje cells of motor skill-trained animals. Complex motor skill training induced strengthening of a subset of parallel fiber synapses onto Purkinje cells by forming multiple-synapse boutons (MSBs) contacting spine pairs arising from the same dendrite, whereas MSB-neighboring synapses were weakened by reducing the size of the post-synaptic density. Here, we discuss these orchestrated structural modifications of neighboring synapses that may sharpen synaptic weight contrast in local dendritic segments, leading to enhanced signal-to-noise ratio for optimal motor skill retention.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalReviews in the Neurosciences
Volume25
Issue number2
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • Dendritic spine
  • Motor learning
  • Parallel fiber
  • Plasticity
  • Purkinje cell
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Synapses need coordination to learn motor skills'. Together they form a unique fingerprint.

  • Cite this