Synaptic strengthening through activation of Ca2+-permeable AMPA receptors

J. G. Gu, C. Albuquerque, Changjoon Lee, A. B. MacDermott

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Postsynaptic Ca2+ elevation during synaptic transmission is an important trigger for short- and long-term changes in synaptic strength in the vertebrate central nervous system. The AMPA (α-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate) receptors, a subfamily of glutamate receptors, mediate much of the excitatory synaptic transmission in the brain and spinal cord. It has been shown that a subtype of the AMPA receptor is Ca2+- permeable and is present in subpopulations of neurons. When synaptically localized, these receptors should mediate postsynaptic Ca2+ influx, providing a trigger for changes in synaptic strength. Here we show that Ca2+-permeable AMPA receptors are synaptically localized on a subpopulation of dorsal horn neurons, that they provide a synaptically gated route of Ca2+ entry, and that activation of these receptors strengthens synaptic transmission mediated by AMPA receptors. This pathway for postsynaptic Ca2+ influx may provide a new form of activity-dependent modulation of synaptic strength.

Original languageEnglish
Pages (from-to)793-796
Number of pages4
JournalNature
Volume381
Issue number6585
DOIs
Publication statusPublished - 1996 Aug 2
Externally publishedYes

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AMPA Receptors
Synaptic Transmission
Posterior Horn Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
Vertebrates
Spinal Cord
Central Nervous System
Neurons
Brain

ASJC Scopus subject areas

  • General

Cite this

Gu, J. G., Albuquerque, C., Lee, C., & MacDermott, A. B. (1996). Synaptic strengthening through activation of Ca2+-permeable AMPA receptors. Nature, 381(6585), 793-796. https://doi.org/10.1038/381793a0

Synaptic strengthening through activation of Ca2+-permeable AMPA receptors. / Gu, J. G.; Albuquerque, C.; Lee, Changjoon; MacDermott, A. B.

In: Nature, Vol. 381, No. 6585, 02.08.1996, p. 793-796.

Research output: Contribution to journalArticle

Gu, JG, Albuquerque, C, Lee, C & MacDermott, AB 1996, 'Synaptic strengthening through activation of Ca2+-permeable AMPA receptors', Nature, vol. 381, no. 6585, pp. 793-796. https://doi.org/10.1038/381793a0
Gu JG, Albuquerque C, Lee C, MacDermott AB. Synaptic strengthening through activation of Ca2+-permeable AMPA receptors. Nature. 1996 Aug 2;381(6585):793-796. https://doi.org/10.1038/381793a0
Gu, J. G. ; Albuquerque, C. ; Lee, Changjoon ; MacDermott, A. B. / Synaptic strengthening through activation of Ca2+-permeable AMPA receptors. In: Nature. 1996 ; Vol. 381, No. 6585. pp. 793-796.
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