Synergistic effects of functional additives on the physico-mechanical and biological properties of poly(L-lactic acid) composites for cardiovascular implant applications

Eun Young Kang, Bogyu Choi, Wooram Park, Ik Hwan Kim, Dong Keun Han

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Biodegradable poly(L-lactic acid) (PLLA) has been widely used as a promising material for vascular stents. Thermal processing is necessary to manufacture PLLA for cardiovascular stents. However, PLLA is vulnerable to thermal degradation when processed at high temperature. Undesired decrease of molecular weight caused by depolymerization reactions not only reduces the mechanical properties after implantation, but also accelerates the degradation rate in body. 1 In addition, the acidic environment induced by byproducts of the degraded PLLA matrix leads an inflammatory response to the implanted site. Magnesium hydroxide (MH) nanoparticles have been used as a mechanical reinforcing agent and pH neutralizing agent for biomaterials, such as PLLA. 2 In this study, bulk modification of PLLA was performed with addition of thermal stabilizers, plasticizer, and MH nanoparticles to improve their thermal and mechanical properties and suppress acidic byproduct-induced inflammatory response. We believe that the bulk modification of biodegradable PLLA using functional additives will have great potential in various biomedical applications.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Kang, E. Y., Choi, B., Park, W., Kim, I. H., & Han, D. K. (2019). Synergistic effects of functional additives on the physico-mechanical and biological properties of poly(L-lactic acid) composites for cardiovascular implant applications. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.