Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives

Bok Young Kim, Joong Bok Ahn, Hong Woo Lee, Kyoung Sik Moon, Tae Bo Sim, Jae Soo Shin, Soon Kil Ahn, Chung Il Hong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-{4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene} thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.

Original languageEnglish
Pages (from-to)276-285
Number of pages10
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number3
DOIs
Publication statusPublished - 2003 Mar
Externally publishedYes

Keywords

  • Erythrose
  • Glucose utilization
  • Insulin sensitizing agent
  • Ribose
  • Substituted pyrrolidine
  • Thiazolidinedione

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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