The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC50 = 5.5 μM) as a reference compound. In our series, urea compound 1o having 4-chloro-3- trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC50 value of 1.4 μM.
|Number of pages||6|
|Journal||Bulletin of the Korean Chemical Society|
|Publication status||Published - 2011 Apr 20|
- Antiproliferative activity
- Melanoma cell line
ASJC Scopus subject areas