Synthesis and antiproliferative activity of pyridinylcarbonylpyrimidines against melanoma cell line

Hyemi Ahn, Jun A. Lee, Hwan Kim, Chang Hyun Oh, So Ha Lee, Taebo Sim, Jung Mi Hah, Dong Jin Kim, Kyung Ho Yoo

Research output: Contribution to journalArticle

Abstract

The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC50 = 5.5 μM) as a reference compound. In our series, urea compound 1o having 4-chloro-3- trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC50 value of 1.4 μM.

Original languageEnglish
Pages (from-to)1209-1214
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume32
Issue number4
DOIs
Publication statusPublished - 2011 Apr 20

Keywords

  • Antiproliferative activity
  • Melanoma cell line
  • Pyridinylcarbonylpyrimidines

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Ahn, H., Lee, J. A., Kim, H., Oh, C. H., Lee, S. H., Sim, T., Hah, J. M., Kim, D. J., & Yoo, K. H. (2011). Synthesis and antiproliferative activity of pyridinylcarbonylpyrimidines against melanoma cell line. Bulletin of the Korean Chemical Society, 32(4), 1209-1214. https://doi.org/10.5012/bkcs.2011.32.4.1209