Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template

Bo Lei, Kwan Ha Shin, Young Wook Moon, Da Young Noh, Young-Hag Koh, Yonghao Jin, Hyoun Ee Kim

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25 Citations (Scopus)

Abstract

This article reports a novel, simple route for synthesis of sol-gel derived porous, bioactive glass (BG) microspheres using chitosan (CTS) as a biomolecular template in the acid-catalyzed sol-gel process. The use of CTS, which is a natural biocompatible polymer with a unique molecular structure, allowed the synthesis of BG microparticles with a spherical shape, 5-10 μm in size. Furthermore, pores with a size of 5-40 nm were created entirely throughout BG microspheres, which were formed by removing the network of CTS present initially in the CTS-BG composite microparticles via heat-treatment at 600°C for 2 h. These porous BG microspheres induced the vigorous precipitation of apatite crystals on their surface when immersed in simulated body fluid for 24 h, thus suggesting their excellent bioactivity.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalJournal of the American Ceramic Society
Volume95
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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