Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors

Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh Gyu Hahn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression.

Original languageEnglish
Pages (from-to)3234-3237
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number15
DOIs
Publication statusPublished - 2014 Aug 1

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Bioactivity
Serotonin
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. / Yun, Jun; Han, Minsoo; Song, Chiman; Cheon, Seung Hoon; Choi, Kihang; Hahn, Hoh Gyu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 15, 01.08.2014, p. 3234-3237.

Research output: Contribution to journalArticle

Yun, Jun ; Han, Minsoo ; Song, Chiman ; Cheon, Seung Hoon ; Choi, Kihang ; Hahn, Hoh Gyu. / Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2014 ; Vol. 24, No. 15. pp. 3234-3237.
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