Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues

Jae Chul Jung, Seikwan Oh, Won-Ki Kim, Woo K. Park, Jae Yang Kong, Oee Sook Park

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A variety of 4-substituted quinolin-2(1H)-ones were prepared and evaluated for N-methyl-D-aspartate (NMDA) receptor binding site activity and their abilities to inhibit neurotoxicity. The 4-(2-carbethoxyethanamino)- 7-chloro-3-nitroquinolin-2(1H)-one (9b) exhibited favorable NMDA receptor binding site activity and 7-chloro-4-(benzylamino)-3- nitroquinolin-2(1H)-one (9c) showed the most potent neurotoxicity among them. The synthetic strategies involve the use of well known keto ester condensation and reductive ring cyclization of intermediates (2a-d) to afford 4-substituted quinolin-2(1H)-ones.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume40
Issue number4
Publication statusPublished - 2003 Jul 1
Externally publishedYes

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Nitroquinolines
N-Methyl-D-Aspartate Receptors
Binding Sites
Cyclization
Condensation
Esters

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Jung, J. C., Oh, S., Kim, W-K., Park, W. K., Kong, J. Y., & Park, O. S. (2003). Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues. Journal of Heterocyclic Chemistry, 40(4), 617-623.

Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues. / Jung, Jae Chul; Oh, Seikwan; Kim, Won-Ki; Park, Woo K.; Kong, Jae Yang; Park, Oee Sook.

In: Journal of Heterocyclic Chemistry, Vol. 40, No. 4, 01.07.2003, p. 617-623.

Research output: Contribution to journalArticle

Jung, JC, Oh, S, Kim, W-K, Park, WK, Kong, JY & Park, OS 2003, 'Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues', Journal of Heterocyclic Chemistry, vol. 40, no. 4, pp. 617-623.
Jung, Jae Chul ; Oh, Seikwan ; Kim, Won-Ki ; Park, Woo K. ; Kong, Jae Yang ; Park, Oee Sook. / Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues. In: Journal of Heterocyclic Chemistry. 2003 ; Vol. 40, No. 4. pp. 617-623.
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