Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Haeun Lee; Woon Young Song; Minju Kim; Min Wook Lee; Soojeung Kim; Ye Song Park; Kyungwon Kwak; Man Hwan Oh; Hak Joong Kim

doi:10.1021/acs.orglett.8b02789

Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Haeun Lee, Woon Young Song, Minju Kim, Min Wook Lee, Soojeung Kim, Ye Song Park, Kyungwon Kwak, Man Hwan Oh, Hak Joong Kim

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

Original language	English
Pages (from-to)	6476-6479
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.8b02789
Publication status	Published - 2018 Oct 19

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii. / Lee, Haeun; Song, Woon Young; Kim, Minju; Lee, Min Wook; Kim, Soojeung; Park, Ye Song; Kwak, Kyungwon; Oh, Man Hwan; Kim, Hak Joong.

In: Organic Letters, Vol. 20, No. 20, 19.10.2018, p. 6476-6479.

Research output: Contribution to journal › Article › peer-review

Lee, Haeun ; Song, Woon Young ; Kim, Minju ; Lee, Min Wook ; Kim, Soojeung ; Park, Ye Song ; Kwak, Kyungwon ; Oh, Man Hwan ; Kim, Hak Joong. / Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii. In: Organic Letters. 2018 ; Vol. 20, No. 20. pp. 6476-6479.

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title = "Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii",

abstract = "Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.",

author = "Haeun Lee and Song, {Woon Young} and Minju Kim and Lee, {Min Wook} and Soojeung Kim and Park, {Ye Song} and Kyungwon Kwak and Oh, {Man Hwan} and Kim, {Hak Joong}",

note = "Funding Information: This study was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01-056815, NRF2010-0020209) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI17C1657). K.K. is also thankful for the support from IBS-R023-D1.",

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doi = "10.1021/acs.orglett.8b02789",

language = "English",

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AU - Kim, Minju

AU - Lee, Min Wook

AU - Kim, Soojeung

AU - Park, Ye Song

AU - Kwak, Kyungwon

AU - Oh, Man Hwan

AU - Kim, Hak Joong

N1 - Funding Information: This study was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01-056815, NRF2010-0020209) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI17C1657). K.K. is also thankful for the support from IBS-R023-D1.

PY - 2018/10/19

Y1 - 2018/10/19

N2 - Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

AB - Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

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Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Abstract

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