Abstract
Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.
Original language | English |
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Pages (from-to) | 6476-6479 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2018 Oct 19 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry