Abstract
Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.
| Original language | English |
|---|---|
| Pages (from-to) | 6476-6479 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 20 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2018 Oct 19 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii. / Lee, Haeun; Song, Woon Young; Kim, Minju; Lee, Min Wook; Kim, Soojeung; Park, Ye Song; Kwak, Kyungwon; Oh, Man Hwan; Kim, Hak Joong.
In: Organic Letters, Vol. 20, No. 20, 19.10.2018, p. 6476-6479.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii
AU - Lee, Haeun
AU - Song, Woon Young
AU - Kim, Minju
AU - Lee, Min Wook
AU - Kim, Soojeung
AU - Park, Ye Song
AU - Kwak, Kyungwon
AU - Oh, Man Hwan
AU - Kim, Hak Joong
PY - 2018/10/19
Y1 - 2018/10/19
N2 - Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.
AB - Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.
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UR - http://www.scopus.com/inward/citedby.url?scp=85054652534&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.8b02789
DO - 10.1021/acs.orglett.8b02789
M3 - Article
VL - 20
SP - 6476
EP - 6479
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 20
ER -