Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Haeun Lee, Woon Young Song, Minju Kim, Min Wook Lee, Soojeung Kim, Ye Song Park, Kyungwon Kwak, Man Hwan Oh, Hak Joong Kim

Research output: Contribution to journalArticle

Abstract

Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

Original languageEnglish
Pages (from-to)6476-6479
Number of pages4
JournalOrganic Letters
Volume20
Issue number20
DOIs
Publication statusPublished - 2018 Oct 19

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Siderophores
Acinetobacter baumannii
pathogens
Pathogens
Mental Competency
delivery
antibiotics
synthesis
Thermodynamic stability
thermal stability
Demonstrations
Iron
Hot Temperature
Anti-Bacterial Agents
iron
anguibactin
acinetobactin

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii. / Lee, Haeun; Song, Woon Young; Kim, Minju; Lee, Min Wook; Kim, Soojeung; Park, Ye Song; Kwak, Kyungwon; Oh, Man Hwan; Kim, Hak Joong.

In: Organic Letters, Vol. 20, No. 20, 19.10.2018, p. 6476-6479.

Research output: Contribution to journalArticle

Lee, Haeun ; Song, Woon Young ; Kim, Minju ; Lee, Min Wook ; Kim, Soojeung ; Park, Ye Song ; Kwak, Kyungwon ; Oh, Man Hwan ; Kim, Hak Joong. / Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii. In: Organic Letters. 2018 ; Vol. 20, No. 20. pp. 6476-6479.
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