Synthesis and degradation behaviors of PEO/PL/PEO tri-block copolymers

Soo Hong Lee, Soo Hyun Kim, Young Ha Kim, Yang Kyoo Han

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Poly(ethylene oxide)/polylatide/poly(ethylene oxide) (PEO/PL/PEO) tri-block copolymers, which each block is connected by ester bond, were synthesized by coupling reaction of PL with PEO in the presence of pyridine. PL/PEO/PL tri-block copolymer was synthesized by ring opening polymerization of L-lactide initiated by PEO in the presence of stannous octoate. Degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer saline (PBS) at 37±1°C. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (NMR) were used to monitor the change of mass loss, molecular weight and composition of copolymers. In hydrolytic degradation, the PEO/PL/PEO tri-block copolymer with high PEO contents affected the increase of its mass loss, and resulted in the decrease of its molecular weight as well as PEO composition. However, when PL/PEO/PL and PEO/PL/PEO tri-block copolymers had similar PEO contents, PEO/PL/PEO decreased faster in molecular weight and PEO composition than PL/PEO/PL.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalMacromolecular Research
Volume10
Issue number2
DOIs
Publication statusPublished - 2002 Apr

Keywords

  • Biodegradable polymer
  • Hydrolytic degradation
  • Poly(ethylene oxide)
  • Polylactide
  • Tri-block copolymer

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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