Synthesis and evaluation of bone morphogenetic protein (BMP)-loaded hydroxyapatite microspheres for enhanced bone regeneration

Jaeuk Baek, Hyun Do Jung, Tae Sik Jang, Sung Won Kim, Min Ho Kang, Hyoun Ee Kim, Young Hag Koh

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

This study demonstrates a novel, simple way of synthesizing bone morphogenetic protein (BMP)-loaded hydroxyapatite (HA) microspheres for enhanced bone regeneration. To accomplish this, calcium phosphate cement (CPC) microspheres, consisting of α-TCP and TTCP powders, were prepared using water-in-oil (W/O) emulsion, followed by treatment at 37 °C for 3 days to convert the CPC to HA. The BMP-loaded HA microspheres with a well-defined spherical shape had a highly porous structure, which was created by the entanglement of precipitated HA crystals with a needle-like morphology. The unique porous structure with the bone mineral-like HA phase resulted in a considerable improvement in in vitro biocompatibility. In addition, the bone regeneration ability of the HA microspheres was significantly enhanced by BMP loading, which was examined by in vivo animal testing using a rabbit vertical guided bone regeneration model.

Original languageEnglish
Pages (from-to)7748-7756
Number of pages9
JournalCeramics International
Volume42
Issue number6
DOIs
Publication statusPublished - 2016 May 1

Keywords

  • B. Porosity
  • D. Apatite
  • E. Biomedical applications
  • Microsphere

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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