Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim, Yoon Jeong Choi, Mi Sook Kim, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Insup Noh

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

Original languageEnglish
JournalCurrent Applied Physics
Volume7
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2007 Apr 1

Fingerprint

Hyaluronic acid
Addition reactions
Methacrylates
Hydrogel
Hyaluronic Acid
ethylene oxide
Polyethylene oxides
Hydrogels
acids
evaluation
synthesis
rheometers
Electron spectroscopy
Rheometers
hydrochlorides
gelation
Gelation
chemical analysis
Sulfhydryl Compounds
thiols

Keywords

  • Evaluation
  • Hyaluronic acid
  • In situ hydrogel
  • Poly(ethylene oxide)

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science (miscellaneous)

Cite this

Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction. / Kim, Gun Woo; Choi, Yoon Jeong; Kim, Mi Sook; Park, Yongdoo; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung; Noh, Insup.

In: Current Applied Physics, Vol. 7, No. SUPPL.1, 01.04.2007.

Research output: Contribution to journalArticle

Kim, Gun Woo ; Choi, Yoon Jeong ; Kim, Mi Sook ; Park, Yongdoo ; Lee, Kyu Back ; Kim, In Sook ; Hwang, Soon Jung ; Noh, Insup. / Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction. In: Current Applied Physics. 2007 ; Vol. 7, No. SUPPL.1.
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