Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim, Yoon Jeong Choi, Mi Sook Kim, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Insup Noh

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Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

Original languageEnglish
JournalCurrent Applied Physics
Issue numberSUPPL.1
Publication statusPublished - 2007 Apr 1



  • Evaluation
  • Hyaluronic acid
  • In situ hydrogel
  • Poly(ethylene oxide)

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science (miscellaneous)

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