Synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ targeting metabotropic glutamate receptor 5 (mGluR5)

Ji Young Kim; Myung Hee Son; Kihang Choi; Du Jong Baek; Min Kyung Ko; Eun Jeong Lim; Ae Nim Pae; Gyochang Keum; Jae Kyun Lee; Yong Seo Cho; Hyunah Choo; Youn Woo Lee; Byung Seok Moon; Byung Cheol Lee; Ho Young Lee; Sun Joon Min

doi:10.5012/bkcs.2014.35.8.2304

Synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) and [¹¹C]MPEQ targeting metabotropic glutamate receptor 5 (mGluR5)

Ji Young Kim, Myung Hee Son, Kihang Choi, Du Jong Baek, Min Kyung Ko, Eun Jeong Lim, Ae Nim Pae, Gyochang Keum, Jae Kyun Lee, Yong Seo Cho, Hyunah Choo, Youn Woo Lee, Byung Seok Moon, Byung Cheol Lee, Ho Young Lee, Sun Joon Min

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl) quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [¹¹C]MPEQ 3 proved that accumulation of [ ¹¹C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

Original language	English
Pages (from-to)	2304-2310
Number of pages	7
Journal	Bulletin of the Korean Chemical Society
Volume	35
Issue number	8
DOIs	https://doi.org/10.5012/bkcs.2014.35.8.2304
Publication status	Published - 2014 Aug 20

Keywords

In vivo
MPEQ
Metabotropic glutamate receptor 5 (mGluR5)
Neuropathic pain
PET imaging

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.5012/bkcs.2014.35.8.2304

Cite this

Kim, J. Y., Son, M. H., Choi, K., Baek, D. J., Ko, M. K., Lim, E. J., Pae, A. N., Keum, G., Lee, J. K., Cho, Y. S., Choo, H., Lee, Y. W., Moon, B. S., Lee, B. C., Lee, H. Y., & Min, S. J. (2014). Synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) and [¹¹C]MPEQ targeting metabotropic glutamate receptor 5 (mGluR5). Bulletin of the Korean Chemical Society, 35(8), 2304-2310. https://doi.org/10.5012/bkcs.2014.35.8.2304

Kim, JY, Son, MH, Choi, K, Baek, DJ, Ko, MK, Lim, EJ, Pae, AN, Keum, G, Lee, JK, Cho, YS, Choo, H, Lee, YW, Moon, BS, Lee, BC, Lee, HY & Min, SJ 2014, 'Synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) and [¹¹C]MPEQ targeting metabotropic glutamate receptor 5 (mGluR5)', Bulletin of the Korean Chemical Society, vol. 35, no. 8, pp. 2304-2310. https://doi.org/10.5012/bkcs.2014.35.8.2304

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abstract = "The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl) quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [11C]MPEQ 3 proved that accumulation of [ 11C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.",

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AU - Choi, Kihang

AU - Baek, Du Jong

AU - Ko, Min Kyung

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AU - Lee, Jae Kyun

AU - Cho, Yong Seo

AU - Choo, Hyunah

AU - Lee, Youn Woo

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AU - Min, Sun Joon

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