The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl) quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [11C]MPEQ 3 proved that accumulation of [ 11C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.
- In vivo
- Metabotropic glutamate receptor 5 (mGluR5)
- Neuropathic pain
- PET imaging
ASJC Scopus subject areas