Synthesis and nanoparticle encapsulation of 3,5-difuranylvinyl-boradiaza-s- indacenes for near-infrared fluorescence imaging

Sehoon Kim, Tymish Y. Ohulchanskyy, Alexander Baev, Paras N. Prasad

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We report molecular design, synthesis, and photophysical study of a series of near-infrared absorbing and fluorescing dyes, 3,5-difuranylvinyl-boradiaza-s- indacenes, bearing various 5-membered heteroaromatic heads at the 8-position (FBs). The correlation between the molecular structure and the spectral shift has been studied by quantum chemical calculations at various levels (B3LYP/6-31G*, HF/6-31G* and HF/PM3), which conclude that the planarity determined by the bulkiness of the head unit controls the optical bandgap of FBs, by energetically affecting the lowest unoccupied molecular orbital (LUMO) rather than the highest occupied molecular orbital (HOMO). We also show that incorporation of heavy atoms increased the capability of singlet oxygen generation as a result of enhanced intersystem crossing, which makes FBs potentially useful for near-infrared photodynamic therapy. In vitro near-infrared fluorescence imaging of live tumor cells has been demonstrated through a nanocarrier approach, by encapsulating one of the FB dyes in a stable aqueous formulation of organically modified silica nanoparticles which retains the fluorescence efficiency of the hydrophobic dye in water.

Original languageEnglish
Pages (from-to)3181-3188
Number of pages8
JournalJournal of Materials Chemistry
Volume19
Issue number20
DOIs
Publication statusPublished - 2009 Jun 23
Externally publishedYes

Fingerprint

Encapsulation
Coloring Agents
Dyes
Fluorescence
Molecular orbitals
Nanoparticles
Infrared radiation
Imaging techniques
Bearings (structural)
Singlet Oxygen
Photodynamic therapy
Optical band gaps
Silicon Dioxide
Molecular structure
Tumors
Silica
Cells
Atoms
Oxygen
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Cite this

Synthesis and nanoparticle encapsulation of 3,5-difuranylvinyl-boradiaza-s- indacenes for near-infrared fluorescence imaging. / Kim, Sehoon; Ohulchanskyy, Tymish Y.; Baev, Alexander; Prasad, Paras N.

In: Journal of Materials Chemistry, Vol. 19, No. 20, 23.06.2009, p. 3181-3188.

Research output: Contribution to journalArticle

Kim, Sehoon ; Ohulchanskyy, Tymish Y. ; Baev, Alexander ; Prasad, Paras N. / Synthesis and nanoparticle encapsulation of 3,5-difuranylvinyl-boradiaza-s- indacenes for near-infrared fluorescence imaging. In: Journal of Materials Chemistry. 2009 ; Vol. 19, No. 20. pp. 3181-3188.
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