Synthesis and polymerization of methacryloyl-PEG-sulfonic acid as a functional macromer for biocompatible polymeric surfaces

Jun Guk Kim, Jun Sim Sang, Ji Heung Kim, Hyun Kim Soo, Ha Kim Young

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Poly(ethylene glycol)s (PEGs) are unique in their material properties, such as biocompatibility, non-toxicity, and water-solublizing ability, which are extremely useful for a variety of biomedical applications. In addition, a variety of functional PEGs with specific functionality at one or both chain ends have been synthesized for many specialized applications. Surface modifications using PEG have been demonstrated to decrease protein adsorption and platelet or cell adhesion on biomaterials. Furthermore, PEGs having anionic sulfonate terminal units have been proven to enhance the blood compatibility of materials, which has been demonstrated by the negative cilia concept. The preparation of telechelic PEGs having a sulfonic acid group at one end and a polymerizable methacryloyl group at the other is an interesting undertaking for providing macromers that can be used in various vinyl copolymerization and gel systems. In this paper, preliminary results on the synthesis and polymerization behavior of a novel PEG macromer is described with the aim of identifying a biocompatible material for applications in various blood-contacting devices.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalMacromolecular Research
Volume12
Issue number4
DOIs
Publication statusPublished - 2004 Aug

Keywords

  • Biomaterials
  • Blood-compatibiltity
  • Methacryloyl group
  • PEG macromer
  • Surface modification

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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