@article{a348f4576c884f35a44b431a813ce740,
title = "Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14",
abstract = "The TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile.",
keywords = "CDK inhibitor, CDK14, CDK15, CDK16, CDK17, CDK18, Cell cycle, Covalent kinase inhibitor, Mitosis, TAIRE kinase",
author = "Ferguson, {Fleur M.} and Doctor, {Zainab M.} and Ficarro, {Scott B.} and Marto, {Jarrod A.} and Kim, {Nam Doo} and Taebo Sim and Gray, {Nathanael S.}",
note = "Funding Information: This work was funded by the following grants; R21CA188881 , R01CA219850 , DFCI Strategic Research Initiative, United States. Funding Information: This work was funded by the following grants; R21CA188881, R01CA219850, DFCI Strategic Research Initiative, United States. J.A.M. is a member of the SAB of Devices. N.S.G. is a founder, SAB member, and equity holder in Gatekeeper, Syros, Petra, C4, B2S, and Soltego. The Gray lab receives or has received research funding from Novartis, Takeda, Astellas, Taiho, Jansen, Kinogen, Her2llc, Deerfield, and Sanofi. N.S.G. F.M.F. and Z.M.D. are inventors on a patent application covering chemical matter in this publication owned by Dana-Farber Cancer Institute. S.B.F, N.D.K. and T.S. have no conflicts to declare Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = aug,
day = "1",
doi = "10.1016/j.bmcl.2019.05.024",
language = "English",
volume = "29",
pages = "1985--1993",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "15",
}
