Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates

Ji Young Kim, Jae-Seung Lee

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.

Original languageEnglish
Pages (from-to)4564-4569
Number of pages6
JournalNano Letters
Volume9
Issue number12
DOIs
Publication statusPublished - 2009 Dec 9

Fingerprint

Gold
DNA
deoxyribonucleic acid
assembly
gold
Nanoparticles
nanoparticles
synthesis
Dithiothreitol
Color
color
Surface plasmon resonance
surface plasmon resonance
Stoichiometry
stoichiometry
Melting
adjusting
melting

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates. / Kim, Ji Young; Lee, Jae-Seung.

In: Nano Letters, Vol. 9, No. 12, 09.12.2009, p. 4564-4569.

Research output: Contribution to journalArticle

@article{66d2efbf89b64e61abaffad9ac01fe61,
title = "Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates",
abstract = "We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.",
author = "Kim, {Ji Young} and Jae-Seung Lee",
year = "2009",
month = "12",
day = "9",
doi = "10.1021/nl9030709",
language = "English",
volume = "9",
pages = "4564--4569",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates

AU - Kim, Ji Young

AU - Lee, Jae-Seung

PY - 2009/12/9

Y1 - 2009/12/9

N2 - We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.

AB - We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.

UR - http://www.scopus.com/inward/record.url?scp=71949111995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71949111995&partnerID=8YFLogxK

U2 - 10.1021/nl9030709

DO - 10.1021/nl9030709

M3 - Article

VL - 9

SP - 4564

EP - 4569

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 12

ER -