Synthesis and thermodynamically controlled anisotropic assembly of DNA-silver nanoprism conjugates for diagnostic applications

Ji Young Kim; Jae Seung Lee

doi:10.1021/cm102984m

Synthesis and thermodynamically controlled anisotropic assembly of DNA-silver nanoprism conjugates for diagnostic applications

Ji Young Kim, Jae Seung Lee

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

We have synthesized DNA-silver nanoprism conjugates using the thiol-silver interaction and have assembled them into anisotropic structures with distinctive optical properties simply by controlling thermodynamic conditions. The reversible assembly formation takes advantage of the natural anisotropic architecture of the silver nanoprisms and the cooperative properties of their DNA conjugates. The anisotropic assemblies have been observed not only ex situ by TEM but also in situ in a solution by UV-vis spectroscopy. We have further investigated biodiagnostic applications of the DNA-silver nanoprism conjugates for the colorimetric and quantitative detection of DNA with high selectivity and sensitivity in the full visible range based upon their unique distant-dependent optical properties.

Original language	English
Pages (from-to)	6684-6691
Number of pages	8
Journal	Chemistry of Materials
Volume	22
Issue number	24
DOIs	https://doi.org/10.1021/cm102984m
Publication status	Published - 2010 Dec 28

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Materials Chemistry

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abstract = "We have synthesized DNA-silver nanoprism conjugates using the thiol-silver interaction and have assembled them into anisotropic structures with distinctive optical properties simply by controlling thermodynamic conditions. The reversible assembly formation takes advantage of the natural anisotropic architecture of the silver nanoprisms and the cooperative properties of their DNA conjugates. The anisotropic assemblies have been observed not only ex situ by TEM but also in situ in a solution by UV-vis spectroscopy. We have further investigated biodiagnostic applications of the DNA-silver nanoprism conjugates for the colorimetric and quantitative detection of DNA with high selectivity and sensitivity in the full visible range based upon their unique distant-dependent optical properties.",

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AU - Lee, Jae Seung

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N2 - We have synthesized DNA-silver nanoprism conjugates using the thiol-silver interaction and have assembled them into anisotropic structures with distinctive optical properties simply by controlling thermodynamic conditions. The reversible assembly formation takes advantage of the natural anisotropic architecture of the silver nanoprisms and the cooperative properties of their DNA conjugates. The anisotropic assemblies have been observed not only ex situ by TEM but also in situ in a solution by UV-vis spectroscopy. We have further investigated biodiagnostic applications of the DNA-silver nanoprism conjugates for the colorimetric and quantitative detection of DNA with high selectivity and sensitivity in the full visible range based upon their unique distant-dependent optical properties.

AB - We have synthesized DNA-silver nanoprism conjugates using the thiol-silver interaction and have assembled them into anisotropic structures with distinctive optical properties simply by controlling thermodynamic conditions. The reversible assembly formation takes advantage of the natural anisotropic architecture of the silver nanoprisms and the cooperative properties of their DNA conjugates. The anisotropic assemblies have been observed not only ex situ by TEM but also in situ in a solution by UV-vis spectroscopy. We have further investigated biodiagnostic applications of the DNA-silver nanoprism conjugates for the colorimetric and quantitative detection of DNA with high selectivity and sensitivity in the full visible range based upon their unique distant-dependent optical properties.

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Synthesis and thermodynamically controlled anisotropic assembly of DNA-silver nanoprism conjugates for diagnostic applications

Abstract

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