Synthesis mechanism and thermal optimization of an economical mesoporous material using silica

Implications for the effective removal or delivery of ibuprofen

Shanmuga Kittappa, Mingcan Cui, Malarvili Ramalingam, Shaliza Ibrahim, Jeehyeong Khim, Yeomin Yoon, Shane A. Snyder, Min Jang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO<inf>2</inf>) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (Δ<inf>adsS</inf>, -0.07 J mol<sup>-1</sup> K<sup>-1</sup>) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP.

Original languageEnglish
Article numbere0130253
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - 2015 Jul 10

Fingerprint

ibuprofen
Mesoporous materials
Ibuprofen
Silicon Dioxide
silica
Hot Temperature
heat
synthesis
sorption
Sorption
Zeolites
cost analysis
Recycling
Entropy
activated carbon
Pore structure
entropy
Unloading
Activated carbon
recycling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Synthesis mechanism and thermal optimization of an economical mesoporous material using silica : Implications for the effective removal or delivery of ibuprofen. / Kittappa, Shanmuga; Cui, Mingcan; Ramalingam, Malarvili; Ibrahim, Shaliza; Khim, Jeehyeong; Yoon, Yeomin; Snyder, Shane A.; Jang, Min.

In: PLoS One, Vol. 10, No. 7, e0130253, 10.07.2015.

Research output: Contribution to journalArticle

Kittappa, Shanmuga ; Cui, Mingcan ; Ramalingam, Malarvili ; Ibrahim, Shaliza ; Khim, Jeehyeong ; Yoon, Yeomin ; Snyder, Shane A. ; Jang, Min. / Synthesis mechanism and thermal optimization of an economical mesoporous material using silica : Implications for the effective removal or delivery of ibuprofen. In: PLoS One. 2015 ; Vol. 10, No. 7.
@article{557d0922521344bfafd6e698622ba253,
title = "Synthesis mechanism and thermal optimization of an economical mesoporous material using silica: Implications for the effective removal or delivery of ibuprofen",
abstract = "Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO2) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (ΔadsS, -0.07 J mol-1 K-1) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87{\%} recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41{\%}, higher than the reported value of SBA-15 (31{\%}). The in vitro release of IBP was faster, almost 100{\%}, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP.",
author = "Shanmuga Kittappa and Mingcan Cui and Malarvili Ramalingam and Shaliza Ibrahim and Jeehyeong Khim and Yeomin Yoon and Snyder, {Shane A.} and Min Jang",
year = "2015",
month = "7",
day = "10",
doi = "10.1371/journal.pone.0130253",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

TY - JOUR

T1 - Synthesis mechanism and thermal optimization of an economical mesoporous material using silica

T2 - Implications for the effective removal or delivery of ibuprofen

AU - Kittappa, Shanmuga

AU - Cui, Mingcan

AU - Ramalingam, Malarvili

AU - Ibrahim, Shaliza

AU - Khim, Jeehyeong

AU - Yoon, Yeomin

AU - Snyder, Shane A.

AU - Jang, Min

PY - 2015/7/10

Y1 - 2015/7/10

N2 - Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO2) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (ΔadsS, -0.07 J mol-1 K-1) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP.

AB - Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO2) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (ΔadsS, -0.07 J mol-1 K-1) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP.

UR - http://www.scopus.com/inward/record.url?scp=84940421591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940421591&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0130253

DO - 10.1371/journal.pone.0130253

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 7

M1 - e0130253

ER -