Synthesis mechanism and thermal optimization of an economical mesoporous material using silica: Implications for the effective removal or delivery of ibuprofen

Shanmuga Kittappa, Mingcan Cui, Malarvili Ramalingam, Shaliza Ibrahim, Jeehyeong Khim, Yeomin Yoon, Shane A. Snyder, Min Jang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO<inf>2</inf>) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (Δ<inf>adsS</inf>, -0.07 J mol<sup>-1</sup> K<sup>-1</sup>) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP.

Original languageEnglish
Article numbere0130253
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - 2015 Jul 10

    Fingerprint

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this