Synthesis of 1H-Pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line

Mohammed I. El-Gamal, Taebo Sim, Jun Hee Hong, Jung Hyuck Cho, Kyung Ho Yoo, Chang Hyun Oh

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15 Citations (Scopus)

Abstract

Synthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalArchiv der Pharmazie
Volume344
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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Keywords

  • 1H-Pyrazole-1-carboxamide
  • 3,4-Diarylpyrazole
  • A375
  • Antiproliferative activity
  • Melanoma

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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