Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Yeon Ho Cho, Kyung Hee Kim, Cheol Hong Cheon

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.

Original languageEnglish
Pages (from-to)901-907
Number of pages7
JournalJournal of Organic Chemistry
Volume79
Issue number3
DOIs
Publication statusPublished - 2014 Feb 7

ASJC Scopus subject areas

  • Organic Chemistry

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