A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.
|Number of pages||7|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2014 Feb 7|
ASJC Scopus subject areas
- Organic Chemistry