Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Yeon Ho Cho; Kyung Hee Kim; Cheol Hong Cheon

doi:10.1021/jo4021908

Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Yeon Ho Cho, Kyung Hee Kim, Cheol Hong Cheon

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.

Original language	English
Pages (from-to)	901-907
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	79
Issue number	3
DOIs	https://doi.org/10.1021/jo4021908
Publication status	Published - 2014 Feb 7

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo4021908

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abstract = "A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.",

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Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Abstract

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