Synthesis of 2-Arylquinolines from 2-Iodoanilines and β-Chloropropiophenones via Palladium-Catalyzed Cascade Reaction

Jooyeon Yoon, Cheol-Hong Cheon

Research output: Contribution to journalArticle


A protocol to access 2-aryl-substituted quinolines from readily available 2-iodoanilines and β-chloropropiophenones, which are synthetic equivalents of acrylophenones, has been developed via the palladium-catalyzed cascade reaction. Various 2-iodoanilines and β-chloropropiophenones were applicable to this protocol to afford the desired quinoline products in good to high yields. Moreover, we demonstrated the usefulness of this protocol in direct synthesis of chloride-bridged dimeric iridium complexes, one of the key intermediates in the synthesis of iridium-based phosphorous materials, without the complete isolation of the quinolines.

Original languageEnglish
JournalAsian Journal of Organic Chemistry
Publication statusPublished - 2019 Jan 1



  • 2-Arylquinolines
  • Cascade reaction
  • Ligand free
  • Palladium
  • β-Chloropropiophenone

ASJC Scopus subject areas

  • Organic Chemistry

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