Synthesis of a PEGylated polymeric pH sensor and its pH sensitivity by fluorescence resonance energy transfer

Sung Woo Hong, Cheol Hee Ahn, June Huh, Won Ho Jo

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A new pH-sensitive polymeric sensor with dispersion stability and biocompatibility is synthesized, and its pH sensitivity is examined on the basis of the fluorescence resonance energy transfer (FRET) efficiency. The polymeric pH sensor has a FRET donor and a FRET acceptor attached to both ends of a pH-sensitive polymeric linker and is also PEGylated to enhance the dispersion stability in aqueous media and biocompatibility. The pH sensor emits the blue color corresponding to the emission of the FRET donor at pHs higher than 7.6, but the pH sensor emits the green color corresponding to the emission of the FRET acceptor at pHs lower than 6.8 when both samples are irradiated at 330 nm, indicating that lowering the pH from 7.6 to 6.8 induces the FRET due to the conformational change of polymeric linker from coil to globule.

Original languageEnglish
Pages (from-to)7694-7700
Number of pages7
JournalMacromolecules
Volume39
Issue number22
DOIs
Publication statusPublished - 2006 Oct 31
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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