Synthesis of Benzoxaphosphole 1-Oxide Heterocycles via a Three-Component Coupling Reaction Involving Arynes, Phosphites, and Ketones

Hee Jin Jeong, Ji Ho Kim, Jae Kyun Lee, Hyo Jae Yoon, Junwon Choi, Seo Jung Han

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient and transition-metal-free three-component reaction with benzynes formed in situ from 2-(trimethylsilyl)aryl triflate, phosphites, and ketones was developed for the synthesis of benzoxaphosphole 1-oxides. An array of benzoxaphosphole 1-oxides were prepared from both activated and non-Activated ketones in moderate to good yields with a broad functional group tolerance. This reaction is useful for preparing organophosphorus compounds encountered in natural products and materials.

Original languageEnglish
Pages (from-to)2192-2196
Number of pages5
JournalOrganic Letters
Volume24
Issue number11
DOIs
Publication statusPublished - 2022 Mar 25

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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