Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Young Wall Kim, Tae Sung Kim, Bo Gil Choi

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3 Citations (Scopus)

Abstract

DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalArchives of Pharmacal Research
Volume31
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

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Keywords

  • ATRA
  • DAAS
  • Leukemia cell differentiation
  • Santonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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