Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Young Wall Kim, Tae Sung Kim, Bo Gil Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalArchives of Pharmacal Research
Volume31
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

HL-60 Cells
Cell Differentiation
Leukemia
Tretinoin
Derivatives
Santonin
Acetals
Structure-Activity Relationship
Granulocytes

Keywords

  • ATRA
  • DAAS
  • Leukemia cell differentiation
  • Santonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation. / Kim, Seung Hyun; Chung, Sun Young; Kim, Young Wall; Kim, Tae Sung; Choi, Bo Gil.

In: Archives of Pharmacal Research, Vol. 31, No. 3, 01.03.2008, p. 300-304.

Research output: Contribution to journalArticle

Kim, Seung Hyun ; Chung, Sun Young ; Kim, Young Wall ; Kim, Tae Sung ; Choi, Bo Gil. / Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation. In: Archives of Pharmacal Research. 2008 ; Vol. 31, No. 3. pp. 300-304.
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