Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Tae Sung Kim, Bo Gil Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D 3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalArchives of pharmacal research
Volume29
Issue number1
DOIs
Publication statusPublished - 2006 Jan 31

Keywords

  • Diacetoxyacetal
  • Dihydroxyvitamin D
  • Leukemia cell differentiation
  • Santonin

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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