Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification

Heejin Kim, Taehoon Kim, Nakyung Choi, Byung Hee Kim, Se Wook Oh, In-Hwan Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Diethylhexyl adipate (DEHA) has been used for various applications in the chemical industry. In particular, DEHA is used as a plasticizer for polyvinyl chloride and its polymers. In this study, DEHA was successfully synthesized via lipase-catalyzed esterification from adipic acid with ethylhexanol in a solvent-free system. An immobilized lipase from Candida antarctica (Novozym 435) was used as a biocatalyst in this reaction. The optimal reaction conditions for the synthesis of DEHA were temperature of 50 °C, an enzyme loading of 5% (based on the total weight of substrate), a vacuum of 6.7 kPa, and a molar ratio 1:2.5 (adipic acid to ethylhexanol). When vacuum was applied, the conversion to DEHA was improved significantly and 100 mol% conversion was obtained within only 3 h under optimal condition.

Original languageEnglish
JournalProcess Biochemistry
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Candida
Esterification
Lipases
Lipase
Vacuum
Biocatalysts
Acids
Plasticizers
Chemical industry
Polyvinyl chlorides
Enzymes
Polymers
Substrates
Chemical Industry
Polyvinyl Chloride
Temperature
dioctyl adipate
Weights and Measures
adipic acid

Keywords

  • Adipic acid
  • Diethylhexyl adipate
  • Esterification
  • Novozym 435
  • Plasticizer

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology

Cite this

Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification. / Kim, Heejin; Kim, Taehoon; Choi, Nakyung; Kim, Byung Hee; Oh, Se Wook; Kim, In-Hwan.

In: Process Biochemistry, 01.01.2019.

Research output: Contribution to journalArticle

Kim, Heejin ; Kim, Taehoon ; Choi, Nakyung ; Kim, Byung Hee ; Oh, Se Wook ; Kim, In-Hwan. / Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification. In: Process Biochemistry. 2019.
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