Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Aiichiro Nagaki, Yuki Uesugi, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journalArticle

29 Citations (Scopus)


Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalChemistry - An Asian Journal
Issue number4
Publication statusPublished - 2013 Apr 1
Externally publishedYes



  • fluorination
  • lithiation
  • microreactors
  • synthetic methods

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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