Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Aiichiro Nagaki, Yuki Uesugi, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalChemistry - An Asian Journal
Volume8
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1
Externally publishedYes

Fingerprint

Fluorides
Lithium Compounds
Electrons
Fluorination
Halogenation
Functional groups

Keywords

  • fluorination
  • lithiation
  • microreactors
  • synthetic methods

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors. / Nagaki, Aiichiro; Uesugi, Yuki; Kim, Heejin; Yoshida, Jun Ichi.

In: Chemistry - An Asian Journal, Vol. 8, No. 4, 01.04.2013, p. 705-708.

Research output: Contribution to journalArticle

Nagaki, Aiichiro ; Uesugi, Yuki ; Kim, Heejin ; Yoshida, Jun Ichi. / Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors. In: Chemistry - An Asian Journal. 2013 ; Vol. 8, No. 4. pp. 705-708.
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