Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Aiichiro Nagaki, Yuki Uesugi, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalChemistry - An Asian Journal
Volume8
Issue number4
DOIs
Publication statusPublished - 2013 Apr

Keywords

  • fluorination
  • lithiation
  • microreactors
  • synthetic methods

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors'. Together they form a unique fingerprint.

Cite this