Abstract
2-Pyrrolidinylmethyl-2′-diphenylphosphino-1,1′-binaphthyl has been found to be a highly reactive and enantioselective N,P-ligand in the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylpropen-2-yl acetate with dimethyl malonate. This axially chiral binaphthyl-based homologated N,P-ligand can be conveniently prepared from enantiomerically pure binaphthol using a five-step reaction sequence, and provides for efficient asymmetric catalysis using the chirality of the binaphthyl skeleton alone.
| Original language | English |
|---|---|
| Pages (from-to) | 1688-1692 |
| Number of pages | 5 |
| Journal | Tetrahedron Asymmetry |
| Volume | 17 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2006 Jul 17 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
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Kim, K. H., Jeong, C. K., Kim, D. H., & Ha, D. C. (2006). Synthesis of homologated binaphthyl N,P-ligands for Pd-catalyzed asymmetric allylic alkylation. Tetrahedron Asymmetry, 17(11), 1688-1692. https://doi.org/10.1016/j.tetasy.2006.06.013