Abstract
2-Pyrrolidinylmethyl-2′-diphenylphosphino-1,1′-binaphthyl has been found to be a highly reactive and enantioselective N,P-ligand in the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylpropen-2-yl acetate with dimethyl malonate. This axially chiral binaphthyl-based homologated N,P-ligand can be conveniently prepared from enantiomerically pure binaphthol using a five-step reaction sequence, and provides for efficient asymmetric catalysis using the chirality of the binaphthyl skeleton alone.
Original language | English |
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Pages (from-to) | 1688-1692 |
Number of pages | 5 |
Journal | Tetrahedron Asymmetry |
Volume | 17 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2006 Jul 17 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry