Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments

Hyeon Ung Kim, Dae Gun Choi, Hyun Jee Lee, Min Suk Shim, Ki Wan Bong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages358-359
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • Cancer therapy
  • Drug release
  • Flow lithography
  • Multi-stimuli responsive drug carrier

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint Dive into the research topics of 'Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments'. Together they form a unique fingerprint.

  • Cite this

    Kim, H. U., Choi, D. G., Lee, H. J., Shim, M. S., & Bong, K. W. (2020). Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 358-359). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.