Synthesis of N-Alkyl-Carbazole Derivatives as 5-HT7R Antagonists

Youngjae Kim, Miyoung Yeom, Soyeon Lee, Jinsung Tae, Hak Joong Kim, Hyewhon Rhim, Jihye Seong, Kyung Il Choi, Sun Joon Min, Hyunah Choo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We designed and synthesized a series of N-alkyl-carbazoles with different alkyl chains and amine moieties, and biological evaluation was performed to discover novel 5-HT7R antagonists. Among 27 synthesized compounds, 20, 21, 23, and 24 showed excellent binding affinities to 5-HT7R (Ki = 65, 64, 55, and 31 nM, respectively), and good selectivity profiles over other serotonin receptors. In functional assays, those compounds showed weak antagonistic activities against 5-HT7R. In particular, the compound 24, 2-(4-(5-(9H-carbazol-9-yl)pentyl)piperazin-1-yl)phenol, could be considered as a potent and selective 5-HT7R ligand with weak antagonistic effect. From the molecular docking study, the aromatic hydroxyl group in 24 was shown to play an important role in binding to 5-HT7R through a hydrogen bonding interaction with Asp142 in the ligand binding pocket of 5-HT7R.

Original languageEnglish
Pages (from-to)1083-1089
Number of pages7
JournalBulletin of the Korean Chemical Society
Issue number9
Publication statusPublished - 2018 Sep


  • 5-HT receptor
  • Antagonist
  • GPCR
  • N-alkyl-carbazole
  • Serotonin

ASJC Scopus subject areas

  • Chemistry(all)


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