Abstract
This study proposes an innovative way of synthesizing porous gelatin/silica bioglass composite microspheres with a nanofibrous structure using emulsion coupled with thermally induced phase separation (TIPS). In particular, a mixture of the solvent (water) and non-solvent (ethanol) was used to induce a unique phase separation of gelatin/silica mixtures (i.e. gelatin/silica hybrid-rich and liquid-rich phases) at - 70 °C for the creation of a nanofibrous structure. All the composite microspheres synthesized with silica contents of 10 wt.%, 15 wt.%, and 20 wt.% had well-defined spherical shapes between 124 and 136 μm in size. In addition, they were comprised of nanofibrous gelatin/silica composite walls (several tens of nanometers in thickness), where the sol-gel derived silica bioglass phase was uniformly distributed throughout the gelatin matrix. The in vitro apatite-forming ability and biocompatibility of the nanofibrous gelatin/silica bioglass composite microspheres was significantly enhanced with an increase in silica content, demonstrating their great potential for the promotion of bone tissue regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 678-685 |
| Number of pages | 8 |
| Journal | Materials Science and Engineering C |
| Volume | 62 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
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Keywords
- Bioactivity
- Bone tissue engineering
- Hybrid
- Microspheres
- Nanofibrous
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering
- Mechanics of Materials
Cite this
Synthesis of nanofibrous gelatin/silica bioglass composite microspheres using emulsion coupled with thermally induced phase separation. / Noh, Da Young; An, Young Hyeon; Jo, In Hwan; Koh, Young-Hag; Kim, Hyoun Ee.
In: Materials Science and Engineering C, Vol. 62, 01.05.2016, p. 678-685.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of nanofibrous gelatin/silica bioglass composite microspheres using emulsion coupled with thermally induced phase separation
AU - Noh, Da Young
AU - An, Young Hyeon
AU - Jo, In Hwan
AU - Koh, Young-Hag
AU - Kim, Hyoun Ee
PY - 2016/5/1
Y1 - 2016/5/1
N2 - This study proposes an innovative way of synthesizing porous gelatin/silica bioglass composite microspheres with a nanofibrous structure using emulsion coupled with thermally induced phase separation (TIPS). In particular, a mixture of the solvent (water) and non-solvent (ethanol) was used to induce a unique phase separation of gelatin/silica mixtures (i.e. gelatin/silica hybrid-rich and liquid-rich phases) at - 70 °C for the creation of a nanofibrous structure. All the composite microspheres synthesized with silica contents of 10 wt.%, 15 wt.%, and 20 wt.% had well-defined spherical shapes between 124 and 136 μm in size. In addition, they were comprised of nanofibrous gelatin/silica composite walls (several tens of nanometers in thickness), where the sol-gel derived silica bioglass phase was uniformly distributed throughout the gelatin matrix. The in vitro apatite-forming ability and biocompatibility of the nanofibrous gelatin/silica bioglass composite microspheres was significantly enhanced with an increase in silica content, demonstrating their great potential for the promotion of bone tissue regeneration.
AB - This study proposes an innovative way of synthesizing porous gelatin/silica bioglass composite microspheres with a nanofibrous structure using emulsion coupled with thermally induced phase separation (TIPS). In particular, a mixture of the solvent (water) and non-solvent (ethanol) was used to induce a unique phase separation of gelatin/silica mixtures (i.e. gelatin/silica hybrid-rich and liquid-rich phases) at - 70 °C for the creation of a nanofibrous structure. All the composite microspheres synthesized with silica contents of 10 wt.%, 15 wt.%, and 20 wt.% had well-defined spherical shapes between 124 and 136 μm in size. In addition, they were comprised of nanofibrous gelatin/silica composite walls (several tens of nanometers in thickness), where the sol-gel derived silica bioglass phase was uniformly distributed throughout the gelatin matrix. The in vitro apatite-forming ability and biocompatibility of the nanofibrous gelatin/silica bioglass composite microspheres was significantly enhanced with an increase in silica content, demonstrating their great potential for the promotion of bone tissue regeneration.
KW - Bioactivity
KW - Bone tissue engineering
KW - Hybrid
KW - Microspheres
KW - Nanofibrous
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UR - http://www.scopus.com/inward/citedby.url?scp=84957990198&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2016.02.017
DO - 10.1016/j.msec.2016.02.017
M3 - Article
C2 - 26952472
AN - SCOPUS:84957990198
VL - 62
SP - 678
EP - 685
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -