Synthesis of new 3-arylisoquinolinamines

Effect on topoisomerase I inhibition and cytotoxicity

Won Jea Cho, Sun Young Min, Thanh Nguyen Le, Tae Sung Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.

Original languageEnglish
Pages (from-to)4451-4454
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number24
DOIs
Publication statusPublished - 2003 Dec 15
Externally publishedYes

Fingerprint

Type I DNA Topoisomerase
Cytotoxicity
Structure-Activity Relationship
Tumor Cell Line
Tumors
Cells
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of new 3-arylisoquinolinamines : Effect on topoisomerase I inhibition and cytotoxicity. / Cho, Won Jea; Min, Sun Young; Le, Thanh Nguyen; Kim, Tae Sung.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 24, 15.12.2003, p. 4451-4454.

Research output: Contribution to journalArticle

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