Synthesis of novel biodegradable cationic dendrimers

Jin Seong Lee, June Huh, Cheol Hee Ahn, Minhyung Lee, Tae Gwan Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Dendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by 1H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D2O at 37°C. The degradation rate depends upon the steric hindrance and reactivity caused by the bulkiness and compact structure of the dendrons. All of the synthesized dendrons were degraded within a month, while 60% of the ester groups in the sterically crowded dendrimers were degraded over the same time period. The cytotoxicity of the dendrons was evaluated by the MTT assay on a 293T cell line which indicated that the obtained dendrons were completely non-toxic. These non-toxic, biodegradable cationic dendrons and dendrimers are believed to have potential applications in the biomedical field.

Original languageEnglish
Pages (from-to)1608-1614
Number of pages7
JournalMacromolecular Rapid Communications
Volume27
Issue number18
DOIs
Publication statusPublished - 2006 Sep 22
Externally publishedYes

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Keywords

  • Biodegradable
  • Dendrimers
  • Dendrons
  • Non-toxicity
  • Polyesters

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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