Synthesis of PEO-based glucose-sensitive block copolymers and their application for preparation of superparamagnetic iron oxide nanoparticles

Sangmi Lee, Joo Hyeon Nam, Yoo Jin Kim, Young Jun Cho, Nan Hyeon Kwon, Jae Yeol Lee, Ho Jung Kang, Hoon Tae Kim, Heung Mok Park, Sehoon Kim, Jungahn Kim

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13 Citations (Scopus)

Abstract

Amphiphilic block copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) radical block polymerization of N-vinylimidazole and 3-(methacrylamido)phenylboronic acid using poly (ethylene oxide) (PEO)-based xanthate type of RAFT agent and 2,2′ -azobisisobutyronitrile (AIBN) in dimethylformaide (DMF) at 90∼110 °C for 24 h. Poly(ethylene oxide-b-3-(methacrylamido)phenylboronic acid) and poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamido)phenylboronic acid) were prepared successfully through the sequential monomer addition method. Both block copolymers were found to exhibit glucose-responsive behavior via the feasibility test for complex formation with Alizarin Red S (ARS). The ratio of molecular weight of the poly(N-vinyimidazole) to the poly(3-(methacrylamido) phenylboronic acid) appeared to play an important role in the pH- & glucose- responsive behavior. The resulting block copolymers were used successfully as polymeric stabilizers to prepare water-soluble Fe3O4 nanoparticles. All the materials were characterized by the combination of 1H nuclear magnetic resonance (NMR), size exclusion chromatography (SEC), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and x-ray diffraction (XRD) analyses. Keywords: pH- and glucose-responsive block copolymer, RAFT polymerization, ring-opening polymerization, xanthate- type agent, ARS complex, water-soluble iron oxide nanoparticles.

Original languageEnglish
Pages (from-to)827-834
Number of pages8
JournalMacromolecular Research
Volume19
Issue number8
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

Keywords

  • ARS complex
  • RAFT polymerization
  • Ring-opening polymerization
  • Water-soluble iron oxide nanoparticles
  • Xanthate- type agent
  • pH-and glucose-responsive block copolymer

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Lee, S., Nam, J. H., Kim, Y. J., Cho, Y. J., Kwon, N. H., Lee, J. Y., Kang, H. J., Kim, H. T., Park, H. M., Kim, S., & Kim, J. (2011). Synthesis of PEO-based glucose-sensitive block copolymers and their application for preparation of superparamagnetic iron oxide nanoparticles. Macromolecular Research, 19(8), 827-834. https://doi.org/10.1007/s13233-011-0810-3