Synthesis of ph-sensitive microparticles for multi-modulated drug release

Kim Hyeon Ung, Min Suk Shim, Ki Wan Bong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of controlled drug delivery systems is essential for side-effect-reduced therapy. Using stop flow lithography (SFL) and acid-degradable monomers, we synthesize pH-sensitive particles for targeted drug delivery. Depending on pH values, the particles exhibit differences in degradation times from minutes to hours. The degradation times of the particles can be also adjusted by controlling the synthesis conditions. To show the multi-modulated drug release, we further synthesize multi-patterned particles. The release of the beads in each compartment is programmed by designing the monomer compositions. Finally, we encapsulate proteins in the particles as a model drug and show their controlled release.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1906-1908
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Fingerprint

Monomers
Controlled drug delivery
Degradation
Lithography
Proteins
Acids
Chemical analysis
Drug Delivery Systems
Targeted drug delivery

Keywords

  • Flow lithography
  • Multi-patterned particles
  • PH-sensitive drug release

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Hyeon Ung, K., Shim, M. S., & Bong, K. W. (2015). Synthesis of ph-sensitive microparticles for multi-modulated drug release. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1906-1908). Chemical and Biological Microsystems Society.

Synthesis of ph-sensitive microparticles for multi-modulated drug release. / Hyeon Ung, Kim; Shim, Min Suk; Bong, Ki Wan.

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 1906-1908.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hyeon Ung, K, Shim, MS & Bong, KW 2015, Synthesis of ph-sensitive microparticles for multi-modulated drug release. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 1906-1908, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 15/10/25.
Hyeon Ung K, Shim MS, Bong KW. Synthesis of ph-sensitive microparticles for multi-modulated drug release. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 1906-1908
Hyeon Ung, Kim ; Shim, Min Suk ; Bong, Ki Wan. / Synthesis of ph-sensitive microparticles for multi-modulated drug release. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 1906-1908
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