Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

Na Yeun Kim, Cheol-Hong Cheon

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

A highly environmentally benign protocol for the synthesis of quinazolinones from anthranilamides and aldehydes via aerobic oxidation was developed in wet DMSO. This protocol is operationally simple, exhibits broad substrate scope, and does not need toxic metal catalysts and bases. In addition, the utility of this transformation was further demonstrated by converting the resulting quinazolinones into other useful products in the same-pot without their isolation.

Original languageEnglish
Pages (from-to)2340-2344
Number of pages5
JournalTetrahedron Letters
Volume55
Issue number15
DOIs
Publication statusPublished - 2014 Apr 9

Fingerprint

Quinazolinones
Dimethyl Sulfoxide
Aldehydes
Metals
Oxidation
Poisons
Catalysts
Substrates
anthranilamide

Keywords

  • Aerobic oxidation
  • Anthranilamide
  • DMSO
  • One-pot synthesis
  • Quinazolinones

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO. / Kim, Na Yeun; Cheon, Cheol-Hong.

In: Tetrahedron Letters, Vol. 55, No. 15, 09.04.2014, p. 2340-2344.

Research output: Contribution to journalArticle

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