Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells

Kyeong Lee, Jee Hyun Lee, Shanthaveerappa K. Boovanahalli, Yongseok Choi, Soo Jin Choo, Ick Dong Yoo, Dong Hee Kim, Mi Young Yun, Gye Won Lee, Gyu Yong Song

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Abstract

We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity.

Original languageEnglish
Pages (from-to)5567-5575
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Keywords

  • (+)-Decursin
  • (+)-Decursinol
  • (+)-Decursinol angelate
  • Melanin inhibitors

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Lee, K., Lee, J. H., Boovanahalli, S. K., Choi, Y., Choo, S. J., Yoo, I. D., Kim, D. H., Yun, M. Y., Lee, G. W., & Song, G. Y. (2010). Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells. European Journal of Medicinal Chemistry, 45(12), 5567-5575. https://doi.org/10.1016/j.ejmech.2010.09.006