Abstract
In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-3- (methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone in dimethylformamide (DMF) at 110 °C, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized in DMF at 90 °C for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 °C for 28 h. All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior of the block copolymers using UV/visible spectrophotometer.
| Original language | English |
|---|---|
| Pages (from-to) | 1173-1180 |
| Number of pages | 8 |
| Journal | Macromolecular Research |
| Volume | 20 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2012 Nov 1 |
| Externally published | Yes |
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Keywords
- Iron oxide nanoparticles
- PEO-based RAFT agent
- Phase transition behavior
- RAFT radical copolymerization
- Water-soluble triblock copolymers
ASJC Scopus subject areas
- Chemical Engineering(all)
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry
Cite this
Synthesis of stimuli-responsive PEO-based triblock copolymers and their applications for preparation of iron oxide nanoparticles. / Nam, Joo Hyun; Choi, Woo Seok; Lee, Jae Hyeok; Kwon, Nan Hyun; Kang, Ho Jung; Lee, Jae Yeol; Kim, Sehoon; Kim, Jungahn.
In: Macromolecular Research, Vol. 20, No. 11, 01.11.2012, p. 1173-1180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of stimuli-responsive PEO-based triblock copolymers and their applications for preparation of iron oxide nanoparticles
AU - Nam, Joo Hyun
AU - Choi, Woo Seok
AU - Lee, Jae Hyeok
AU - Kwon, Nan Hyun
AU - Kang, Ho Jung
AU - Lee, Jae Yeol
AU - Kim, Sehoon
AU - Kim, Jungahn
PY - 2012/11/1
Y1 - 2012/11/1
N2 - In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-3- (methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone in dimethylformamide (DMF) at 110 °C, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized in DMF at 90 °C for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 °C for 28 h. All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior of the block copolymers using UV/visible spectrophotometer.
AB - In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-3- (methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone in dimethylformamide (DMF) at 110 °C, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized in DMF at 90 °C for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 °C for 28 h. All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior of the block copolymers using UV/visible spectrophotometer.
KW - Iron oxide nanoparticles
KW - PEO-based RAFT agent
KW - Phase transition behavior
KW - RAFT radical copolymerization
KW - Water-soluble triblock copolymers
UR - http://www.scopus.com/inward/record.url?scp=84871042412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871042412&partnerID=8YFLogxK
U2 - 10.1007/s13233-012-0173-4
DO - 10.1007/s13233-012-0173-4
M3 - Article
AN - SCOPUS:84871042412
VL - 20
SP - 1173
EP - 1180
JO - Macromolecular Research
JF - Macromolecular Research
SN - 1598-5032
IS - 11
ER -