Abstract
In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-3- (methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone in dimethylformamide (DMF) at 110 °C, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized in DMF at 90 °C for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 °C for 28 h. All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior of the block copolymers using UV/visible spectrophotometer.
Original language | English |
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Pages (from-to) | 1173-1180 |
Number of pages | 8 |
Journal | Macromolecular Research |
Volume | 20 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2012 Nov |
Keywords
- Iron oxide nanoparticles
- PEO-based RAFT agent
- Phase transition behavior
- RAFT radical copolymerization
- Water-soluble triblock copolymers
ASJC Scopus subject areas
- Chemical Engineering(all)
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry