Synthesis of symmetrical diarylalkyne from palladium-catalyzed decarboxylative couplings of propiolic acid and aryl bromides under water

Kyungho Park, Goun Bae, Ahbyeol Park, Yong Kim, Jaehoon Choe, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Symmetric diarylalkynes were obtained from the decarboxylative coupling reactions of aryl bromides and propiolic acid in water solvent condition. In the presence of phase transfer surfactant C18H37N(CH 3)3Cl, the catalytic system of both Pd(PPh 3)2Cl2/dppb and Pd(TPPMS)2Cl 2/TPPMS afforded the desired coupled products in good yields.

Original languageEnglish
Pages (from-to)576-580
Number of pages5
JournalTetrahedron Letters
Volume52
Issue number5
DOIs
Publication statusPublished - 2011 Feb 2
Externally publishedYes

Keywords

  • Decarboxylative coupling
  • Microwave
  • Palladium
  • Propiolic acid
  • Water

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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